Red Reishi May Support Cancer Treatment

With a name like the Mushroom of Immortality, who could resist taking this traditional herbal remedy whose medicinal use spans over 2000 years. Known as Reishi in Japan, and ling zhi in China, its name roughly translates as ‘soul mushroom’ or ‘spiritual plant’, and latest research suggests it can help support conventional cancer treatments.

Ling zhi featured in the earliest Chinese pharmacopoeia, where it was classed as ‘Superior’ and rated as number 1 in a list of 120 superior medicines – even above Panax ginseng. Taoist monks used Reishi to promote a calm, meditative state, to improve memory and to achieve a long, healthy life.

As the most exalted herb in ancient times, Reishi soon became rare in the wild, and specimens found growing on old oak, cherry or plum trees were reserved for use by the Emperor.

Fast forward several millennia, and Reishi is now grown commercially and available to all although it is not that well-known in the West.

What is Reishi?

ReishiReishi consists of the dried, fruiting body of a fungus, Ganoderma lucidum, which is too woody, fibrous and bitter to eat as a food.

Six different colours of Reishi are recognised in traditional Chinese medicine: red, green, white, yellow, purple and black. Of these, red Reishi (hong ling zhi) is considered the most potent, especially if the cap assumes a swirled, ram’s horn shape.

Reishi contains over 100 different triterpenes, including a unique group of lucidenic and ganoderic acids that have a similar structure to steroid hormones. These are present in the fruiting body and in the mycelium, or root-like structures that grow into wood to extract nutrients.

Reishi mushrooms are dried and consumed in the form of teas, tinctures, or finely ground to make tablets or capsules.

Reishi mycelium was not traditionally used as a tonic herb, but researchers have found it is a richer source of the same active triterpenes, and these softer roots are easier to grow and compact to produce tablets and capsules.

What is Reishi used for?

Reishi is one of the most widely researched traditional herbal medicines in China and Japan. Most scientific studies have focused on how it affects immunity, the circulation, glucose regulation and liver function. Little of this research has been translated into English, however, and few studies have been performed in the west, which is largely why it does not have the same popularity over here.

Reishi and cancer support

Research from China suggests that Reishi increases the activity of T-lymphocytes involved in fighting infections and targeting abnormal cells. In traditional herbal medicine, it is used to boost immunity after chemotherapy or radiotherapy.

Reishi is not a cure for cancer, but may support usual medical treatment. This suggestion comes from no less a body than the Cochrane Library who provide trusted evidence to help people make informed decisions for better health.

Reishi mushroomsA recent Cochrane systematic review assessed the available evidence for using Reishi to support immunity and quality of life in people with cancer. They pooled the data from 5 randomised controlled trials, and found a significant benefit.

People who were given Reishi extracts alongside chemo/radiotherapy were 50% more likely to respond positively compared to chemo/radiotherapy alone. This benefit was due to an increased percentage of tumour fighting cells (CD3, CD4, CD8 and Natural Killer cells).

Four studies showed that taking Reishi improved quality of life compared with controls. Reishi used alone did not show the same benefits as the combined therapy.

The reviewers concluded that, although there was currently insufficient evidence to justify the use of Reishi on its own as a first-line treatment for cancer,  it could be used together with conventional treatment due to its potential for stimulating host immunity and enhancing tumour responses to treatment.

It was generally well tolerated by most participants with only a few experiencing minor side effects, including nausea and insomnia.

The reviewers suggested that use of the extract should be judicious, after thorough consideration of cost-benefit and patient preference. They added that it remains uncertain whether Reishi helps to prolong long-term cancer survival.

IMPORTANT: If you have cancer, or have undergone chemotherapy or radiotherapy, you should only use Reishi under medical supervision.

If your doctors are interested in reading the Cochrane Systematic Review, the full reference is: Jin X, Ruiz Beguerie J, Sze DMY, Chan GCF. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database of Systematic Reviews 2016, Issue 4. Art. No.: CD007731. DOI: 10.1002/14651858.CD007731.pub3  and they can access the research by clicking here.

Reishi and heart disease risk factors

Reishi contains four peptides that act in a similar way to ACE inhibitor antihypertensive drugs. In a Japanese study involving 50 people with essential hypertension  taking Reishi extracts for 6 months lowered average blood pressure from 156/103 mmHg to 137/93 mmHg. This improvement of 19/10 mmHg is better than is seen with many prescribed antihypertensive drugs.

Another Cochrane systematic review found too little evidence available to assess its benefits. They found five trials, involving a total of 398 people, one of which was translated from China, and one of which was unpublished. Three of the studies were in people with type 2 diabetes mellitus and used doses of 1.4 g to 3 g per day for 12 to 16 weeks. They found no significant improvements in fasting plasma glucose levels, blood pressure or triglycerides and concluded that the small number of randomised controlled trials did not support the use of Reishi for treating cardiovascular risk factors in people with type 2 diabetes, and that more placebo-controlled research was needed.

Reishi as a general tonic

Most people who take Reishi use it as a general tonic to help them remain healthy, based on traditional use. It is especially popular during winter months to boost immunity against colds.

The effects of Reishi are enhanced by vitamin C which increases absorption of the active components.

NB If you have any medical condition or are taking any prescribed medicines, only use Reishi under clinical supervision – especially if you are taking immunosuppressive drugs, anticoagulants or cholesterol-lowering medication.

Reishi may increase the sedative effects of certain drugs.

Do not take if you are on anticoagulant medication, as Reishi may have a blood thinning effect similar to that of aspirin.

If in doubt always check with your doctor or a pharmacist.

Image credits: bdspn/stockfresh; sashimomura/flickr; gljivarsko_drustvo_nis/flickr

About DrSarahBrewer

Dr Sarah Brewer MSc (Nutr Med), MA (Cantab), MB, BChir, RNutr, MBANT qualified from Cambridge University with degrees in Natural Sciences, Medicine and Surgery. After working in general practice, she gained a Master's degree in Nutritional Medicine from the University of Surrey. Sarah is a licensed Medical Doctor, a Registered Nutritionist, a Registered Nutritional Therapist and the award winning author of over 60 popular self-help books. Sarah's other websites are and

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